2113 Corneal transplantation in high-risk patients: Influence of HLA matching

To quantify clinical and operative factors influencing comeal graft outcome. MeVlods Multifactorial analysis of 2242 grafts registered by United Kingdom Transplant Service from July 1987 to June 1990. Results Increased risk of graft failure with: pm operative stmmal oedema; small trechine size: difference in donor and recioient sizes areater than 0.25 mm: and mixed ccntinuous and interrupted sutures. Poorer 3month visuai acuity with: glaucoma and low visual acuity preoperatively; small trephine size; and combined vitreous surgery. Higher 5 month astigmatism with: interupted sutures. Conclusions Effects of factors were generally in the same direction for each outcome measure. Only large scale, randomised. controlled trials will provide definitive answers to preferred operative techniques.